The first couple had disobeyed God's express commandment. They had eaten the fruit from the tree of the knowledge of good and evil. Judgement was being rendered (Genesis 3:14-19):
At first glance it seemed as though the sentence that was passed was completely hopeless. But a deeper study reveals the grace even in the midst of mankind's punishment.
Now I don't like snakes, I find them creepy. Something about their slithery, slippery motions makes my skin crawl. But that's not what God meant by enmity between the snake and the woman. In Bible prophecy the serpent represents the devil while the woman represents the church (God's people).
There is a natural separation between the people of God and the devil. A built-in warning system. Even as early as these moments after the Fall, God gives the message of salvation. The promised Seed from the woman would bruise the head of the serpent.
This verse is a reminder that God wants to save us. Even while we experience the consequences of our sin, God provides a message of hope. Redemption and victory are ours because we serve a risen Savior. What an awesome God!